ETHANOLAMINE MIMICS INSULIN EFFECTS INVITRO

被引：8

作者：

BARSEGHIAN, G

PAPOIAN, T

HWANG, DL

ROITMAN, A

LEVRAN, A

机构：

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1984年 / 121卷 / 01期

关键词：

D O I：

10.1016/0006-291X(84)90738-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comparative effects of insulin and ethanolamine on 14CO2 production and lipid synthesis from [U[uridyl]-14C]-D-glucose in isolated rat adipocytes were studied. Ethanolamine (10 mM) increased 14CO2 production (glucose oxidation) about 5-fold and lipogenesis about 3-fold as compared to the control. Ethanolamine was more efficient than 25 .mu.U/ml insulin regarding both parameters, but its was less efficient than 200 .mu.U/ml insulin in glucose oxidation, and equally potent in lipogenesis. The combination of ethanolamine and insulin was more active than insulin alone. Mechanisms of ethanolamine action include facilitation of glucose transport and increase of pyruvate dehydrogenase activity.

引用

页码：413 / 419

页数：7

共 25 条

[1]

BARESGHIAN G, 1966, BIOL J ARMENIA, V19, P26

[2]

BARSEGHIAN G, 1965, DOKLADY ACAD SCI ARM, V40, P109

[3]

BARSEGHIAN G, 1964, BRAIN BIOCH, V1, P151

[4]

BARSEGHIAN G, 1957, P YEREVAN ZOO VET I, V21, P25