CHARACTERIZATION OF FIBRONECTIN ATTACHMENT BY A HUMAN TRANSITIONAL CELL-CARCINOMA LINE, T24

被引：18

作者：

COPLEN, DE

BROWN, EJ

MCGARR, J

RATLIFF, TL

机构：

[1] WASHINGTON UNIV,MED CTR,SCH MED,DEPT UROL,216 S KINGSHIGHWAY,ST LOUIS,MO 63178

[2] JEWISH HOSP ST LOUIS,DEPT PATHOL,DIV UROL,ST LOUIS,MO 63110

[3] JEWISH HOSP ST LOUIS,DEPT MED,ST LOUIS,MO 63110

[4] JEWISH HOSP ST LOUIS,DEPT MICROBIOL & IMMUNOL,ST LOUIS,MO 63110

[5] INFECT DIS ASSOC WESTERN PENN INC,PITTSBURGH,PA

来源：

JOURNAL OF UROLOGY | 1991年 / 145卷 / 06期

关键词：

TRANSITIONAL CELL CARCINOMA; BLADDER;

D O I：

10.1016/S0022-5347(17)38621-4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The ability of transitional cell carcinoma cells to adhere to and invade the extracellular matrix is important in invasion and metastasis. The glycoprotein fibronectin is associated with laminin and Type IV collagen in the bladder basement membrane. We characterized the interaction between T-24 cells, a cell line derived from an invasive transitional cell tumor, and fibronectin. The cells use the alpha-5-beta-1 heterodimeric integrin receptor complex to mediate adherence via the classical (RGDS) fibronectin binding site. The importance of the alpha-5-beta-1 receptor to T-24 function is unknown and under investigation.

引用

页码：1312 / 1315

页数：4

共 27 条

[1] CHEMOTAXIS OF 3T3 AND SV3T3 CELLS TO FIBRONECTIN IS MEDIATED THROUGH THE CELL-ATTACHMENT SITE IN FIBRONECTIN AND A FIBRONECTIN CELL-SURFACE RECEPTOR [J].