ANTHELMINTIC ACTIVITY OF PARAHERQUAMIDE IN DOGS

被引：16

作者：

SHOOP, WL

EARY, CH

MICHAEL, BF

HAINES, HW

SEWARD, RL

机构：

[1] Merck Institute for Therapeutic Research, Rahway, NJ 07065

来源：

VETERINARY PARASITOLOGY | 1991年 / 40卷 / 3-4期

关键词：

D O I：

10.1016/0304-4017(91)90114-B

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the common gastrointestinal nematodes of dogs at a single oral dosage of 0.5, 1.0, or 2.0 mg kg-1. Efficacy was poor (less than 85%) against Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonina, Trichuris vulpis, and Strongyloides stercoralis at the low- and mid-dosage levels. At the high dosage level, good efficacy (91%) was observed only against S. stercoralis. Adverse reactions were observed in all dogs at every dosage level and included depression, ataxia. and protrusion of the nictitating membrane.

引用

页码：339 / 341

页数：3