NEOCLERODANE DITERPENOIDS FROM TEUCRIUM-GRACILE

被引：18

作者：

BRUNO, M

DOMINGUEZ, G

LOURENCO, A

PIOZZI, F

RODRIGUEZ, B

SAVONA, G

DELATORRE, MC

ARNOLD, NA

机构：

[1] CSIC,INST QUIM,E-28006 MADRID,SPAIN

[2] UNIV CAMERINO,IST BIOL FARMACEUT,I-62032 CAMERINO,ITALY

来源：

PHYTOCHEMISTRY | 1991年 / 30卷 / 11期

关键词：

TEUCRIUM-GRACILE; LABIATAE; NEOCLERODANE DERIVATIVES; TEUGRACILINS-A; TEUGRACILIN-B; TEUGRACILIN-C; 3-0-DEACETYLTEUGRACILIN-A;

D O I：

10.1016/0031-9422(91)80092-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new neo-clerodane diterpenoids have been isolated from the aerial parts of Teucrium gracile. The structures of these compounds, 3-beta,19-diacetoxy-4-alpha,18;15,16-diepoxy-6-beta-hydroxy-neo-cleroda-13(16),14-dien-20,12S-olide (teugracilin A), 19-acetoxy-4-alpha,18;15,16-diepoxy-3-beta,6-beta-dihydroxy-neo-cleroda-13(16),14-dien-20,12S-olide (3-O-deacetylteugracilin A), 19-acetoxy-4-alpha,18;15,16-diepoxy-3-beta,6-alpha-dihydroxy-neo-cleroda-13(16),14-dien-20,12S-olide (teugracilin B) and 12-zeta,19-diacetoxy-4-alpha,18;15,16-diepoxy-neo-cleroda-13(16),14-diene-3-beta,6-alpha-diol (teugracilin C), were established by chemical and spectroscopic means. In addition, the already known neo-clerodane derivative teumicropodin [3-beta,19-diacetoxy-4-alpha,18;15,16-diepoxy-6-alpha-hydroxy-neo-cleroda-13(16),14-dien-20,12S-olide] has been isolated from the same source.

引用

收藏

页码：3693 / 3697

页数：5

相关论文

共 12 条

[1] NEOCLERODANE DITERPENOIDS FROM TEUCRIUM-OLIVERIANUM [J].

BRUNO, M ;

OMAR, AA ;

PERALES, A ;

PIOZZI, F ;

RODRIGUEZ, B ;

SAVONA, G ;

DELATORRES, MC .

PHYTOCHEMISTRY, 1991, 30 (01) :275-282

[2] 2 C-10 OXYGENATED NEOCLERODANE DITERPENOIDS FROM TEUCRIUM-PESTALOZZAE [J].

DELATORRE, MC ;

RODRIGUEZ, B ;

BRUNO, M ;

SAVONA, G ;

PIOZZI, F ;

PERALES, A ;

TORRES, MR ;

SERVETTAZ, O .

PHYTOCHEMISTRY, 1990, 29 (07) :2229-2233

[3] NEO-CLERODANE DITERPENOIDS FROM TEUCRIUM-PESTALOZZAE, TEUCRIUM-ODONTITES AND TEUCRIUM-MICROPHYLLUM [J].

DELATORRE, MC ;

BRUNO, M ;

SAVONA, G ;

PIOZZI, F ;

RODRIGUEZ, B ;

SERVETTAZ, O .

PHYTOCHEMISTRY, 1990, 29 (03) :988-989

[4] NEO-CLERODANE DITERPENOIDS FROM TEUCRIUM-MICROPODIOIDES [J].

DELATORRE, MC ;

RODRIGUEZ, B ;

BRUNO, M ;

SAVONA, G ;

PIOZZI, F ;

SERVETTAZ, O .

PHYTOCHEMISTRY, 1988, 27 (01) :213-216

[5] CORRECT STRUCTURES OF MONTANIN-C, TEUPOLIN-I, AND 12-EPI-TEUCVIN, 3 (12R)-NEOCLERODAN-20,12-OLIDES ISOLATED FROM THE TEUCRIUM SPECIES [J].

FAYOS, J ;

FERNANDEZGADEA, F ;

PASCUAL, C ;

PERALES, A ;

PIOZZI, F ;

RICO, M ;

RODRIGUEZ, B ;

SAVONA, G .

JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (10) :1789-1793

[6] NEOCLERODANE DITERPENOIDS FROM TEUCRIUM-PYREN AICUM AND TEUCRIUM-SUBSPINOSUM [J].

FERNANDEZ, P ;

RODRIGUEZ, B ;

VILLEGAS, JA ;

PERALES, A ;

SAVONA, G ;

PIOZZI, F ;

BRUNO, M .

PHYTOCHEMISTRY, 1986, 25 (06) :1405-1409

[7] THE C-12 AND C-20 CONFIGURATIONS OF SOME NEOCLERODANE DITERPENOIDS ISOLATED FROM TEUCRIUM SPECIES [J].

PASCUAL, C ;

FERNANDEZ, P ;

GARCIAALVAREZ, MC ;

MARCO, JL ;

FERNANDEZGADEA, F ;

DELATORRE, MC ;

HUESORODRIGUEZ, JA ;

RODRIGUEZ, B ;

BRUNO, M ;

PATERNOSTRO, M ;

PIOZZI, F ;

SAVONA, G .

PHYTOCHEMISTRY, 1986, 25 (03) :715-718

[8]

PIOZZI F, 1987, HETEROCYCLES, V25, P807

[9] CRYSTAL-STRUCTURE OF 3-EPICARYOPTIN AND THE REVERSAL OF THE CURRENTLY ACCEPTED ABSOLUTE-CONFIGURATION OF CLERODIN [J].

ROGERS, D ;

UNAL, GG ;

WILLIAMS, DJ ;

LEY, SV ;

SIM, GA ;

JOSHI, BS ;

RAVINDRANATH, KR .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (03) :97-99

[10] NEOCLERODANE DITERPENOIDS FROM TEUCRIUM-LEPICEPHALUM AND TEUCRIUM-BUXIFOLIUM [J].

SAVONA, G ;

PIOZZI, F ;

SERVETTAZ, O ;

RODRIGUEZ, B ;

HUESORODRIGUEZ, JA ;

DELATORRE, MC .

PHYTOCHEMISTRY, 1986, 25 (11) :2569-2572