LOW CONTENT OF MITOCHONDRIAL ATPASE IN BROWN ADIPOSE-TISSUE IS THE RESULT OF POSTTRANSCRIPTIONAL REGULATION

被引：26

作者：

HOUSTEK, J

TVRDIK, P

PAVELKA, S

BAUDYSOVA, M

机构：

[1] Institute of Physiology, Czechoslovak Academy of Sciences

来源：

FEBS LETTERS | 1991年 / 294卷 / 03期

关键词：

BROWN ADIPOSE TISSUE; MITOCHONDRION; ATPASE; CYTOCHROME OXIDASE; TRANSCRIPTION; NUCLEAR GENE;

D O I：

10.1016/0014-5793(91)80666-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mRNA levels of ATPase-beta, ATPase 6, cytochrome oxidase (COX) VIb and COX I subunits were found to be 2.4-13.8-fold higher in brown adipose tissue (BAT) than in heart, skeletal muscle, brain and liver of mice. The comparison with tissue contents of ATPase and COX revealed that the selective, 5-11-fold reduction of ATPase in BAT is not caused by decreased transcription of ATPase genes. Likewise, the ATPase-beta and COX VIb mRNA levels in cultured brown adipocytes were also not influenced by norepinephrine, which activated the expression of the UCP gene by two orders of magnitude. The results indicate that the biosynthesis of mitochondrial ATPase in BAT is post-transcriptionally regulated.

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页码：191 / 194

页数：4

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