A MATHEMATICAL-MODEL FOR THE LEUKOCYTE FILTRATION PROCESS

被引：2

作者：

BRUIL, A ^{[1
]}

BEUGELING, T ^{[1
]}

FEIJEN, J ^{[1
]}

机构：

[1] UNIV TWENTE,DEPT CHEM TECHNOL,7500 AE ENSCHEDE,NETHERLANDS

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1995年 / 45卷 / 02期

关键词：

DEPTH FILTRATION; MATHEMATICAL MODEL; LEUKOCYTE FILTRATION; FILTER EFFICIENCY;

D O I：

10.1002/bit.260450210

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Leukocyte filters are applied clinically to remove leukocytes from blood. In order to optimize leukocyte filters, a mathematical model to describe the leukocyte filtration process was developed by modification of a general theoretical model for depth filtration. The model presented here can be used to predict the time-dependent leukocyte filtration as a function of cell-cell interaction in the filter, filter efficiency, filter capacity, filter dimensions, and leukocyte concentration in the suspension applied to the filter. The results of different leukocyte filtration experiments previously reported in the literature could be well described by the present model. (C) 1995 John Wiley & Sons, Inc.

引用

页码：158 / 164

页数：7

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