GALANIN-CONTAINING NEURONS IN THE SOLITARY NUCLEUS AND LOCUS-COERULEUS OF SPONTANEOUSLY HYPERTENSIVE RATS ARE ASSOCIATED WITH GENETIC-HYPERTENSION

被引：14

作者：

KUNKLER, PE ^{[1
]}

WANG, GM ^{[1
]}

HWANG, BH ^{[1
]}

机构：

[1] INDIANA UNIV, SCH MED, DEPT ANAT, INDIANAPOLIS, IN 46202 USA

来源：

BRAIN RESEARCH | 1994年 / 651卷 / 1-2期

关键词：

GALANIN; GALANIN MESSENGER-RNA; GENETIC HYPERTENSION; LOCUS COERULEUS; NUCLEUS TRACTUS SOLITARIUS;

D O I：

10.1016/0006-8993(94)90718-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spontaneously hypertensive (SHR) rats contained more galanin (GAL) content and GAL mRNA in locus coeruleus (LC) at the prehypertensive, but not at the well-established hypertensive stage, than did age-matched Wistar-Kyoto (WKY) rats. However, there was also more GAL content, but not GAL mRNA, in the nucleus tractus solitarii (NTS) of SHR rats than WKY rats at bath stages. This study suggests that galaninergic neurons in the LC and NTS may participate in the pathogenesis of genetic hypertension.

引用

页码：349 / 352

页数：4

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