CEREBRAL AND BLOOD PHARMACOKINETICS OF IMIPRAMINE AND ITS ACTIVE METABOLITES IN THE PREGNANT RAT

被引：19

作者：

DEVANE, CL

SIMPKINS, JW

STOUT, SA

机构：

[1] UNIV FLORIDA, COLL PHARM, DEPT PHARM PRACTICE, GAINESVILLE, FL 32610 USA

[2] UNIV FLORIDA, COLL MED, DEPT PSYCHIAT, GAINESVILLE, FL 32610 USA

[3] UNIV FLORIDA, COLL PHARM, DEPT PHARMACEUT BIOL, GAINESVILLE, FL 32610 USA

来源：

PSYCHOPHARMACOLOGY | 1984年 / 84卷 / 02期

关键词：

D O I：

10.1007/BF00427450

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A single i.p. dose of imipramine (IMI) was administered to pregnant rats. Whole blood, plasma, and brain concentrations of IMI, desipramine (DMI), and their 2-hydroxylated metabolites were separated by high-pressure liquid chromatography and quantified by fluorescence detection. IMI and DMI rapidly appeared in brain tissue in concentrations greatly exceeding those in whole blood and plasma. The much higher concentration and longer persistence of DMI in brain compared to IMI suggests that the predominant central effects from administered IMI result from biotransformation to DMI. The metabolite:parent area under the curve ratios for the hydroxylated metabolites indicate that their contribution to the pharmacologic effects of IMI and DMI are probably negligible.

引用

页码：225 / 230

页数：6

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