PLASMODIUM-FALCIPARUM - EFFECTS OF AMANTADINE, AN ANTIVIRAL, ON CHLOROQUINE-RESISTANT AND CHLOROQUINE-SENSITIVE PARASITES INVITRO AND ITS INFLUENCE ON CHLOROQUINE ACTIVITY

被引：13

作者：

EVANS, SG ^{[1
]}

HAVLIK, I ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,SCH MED,DEPT EXPTL & CLIN PHARMACOL,7 YORK RD,JOHANNESBURG 2193,SOUTH AFRICA

来源：

BIOCHEMICAL PHARMACOLOGY | 1993年 / 45卷 / 05期

关键词：

D O I：

10.1016/0006-2952(93)90264-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The lysosomotropic nature of amantadine suggested potential as an antimalarial. Sensitivity tests to amantadine hydrochloride alone and in combination with chloroquine were carried out in 96-well microtitre plates using the tritiated hypoxanthine uptake method to measure parasite growth. Amantadine alone has antimalarial activity. Amantadine is more potent against chloroquine-resistant strains. Combinations of amantadine and chloroquine result in slight synergy in both resistant and sensitive strains.

引用

页码：1168 / 1170

页数：3

共 20 条

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