GENERATION OF HUMAN ENDOTHELIN BY CATHEPSIN-E

被引：80

作者：

LEES, WE

KALINKA, S

MEECH, J

CAPPER, SJ

COOK, ND

KAY, J

机构：

[1] UNIV COLL CARDIFF,COLL CARDIFF,DEPT BIOCHEM,POB 903,CARDIFF CF1 1ST,WALES

[2] AMERSHAM INT PLC,DEV GRP,CARDIFF CF4 7YT,WALES

来源：

FEBS LETTERS | 1990年 / 273卷 / 1-2期

关键词：

Big endothelin; big ET; 38 residue precursor of human endothelin-1; Cathepsin D; Cathepsin E; CT; 17 residue C-terminal fragment of the big ET precursor; Endothelin generation; ET; 21 residue endothelin-1; TFA; trifluoroacetic acid;

D O I：

10.1016/0014-5793(90)81060-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Highly-purified cathepsin D processed human big endothelin1-38 into endothelin-like fragments but did not appear to generate endothelin1-21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1-21 and the C-terminal fragment under identical conditions but did not degrade either product further. © 1990.

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页码：99 / 102

页数：4

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