ASPECTS OF METABOLISM OF TAMOXIFEN BY RAT-LIVER MICROSOMES - IDENTIFICATION OF A NEW METABOLITE - E-1-[4-(2-DIMENTYLAMINOETHOXY)-PHENYL]-1, 2-DIPHENYL-1-BUTEN-3-OL N-OXIDE

被引：54

作者：

MCCAGUE, R ^{[1
]}

SEAGO, A ^{[1
]}

机构：

[1] INST CANC RES,CANCER RES CAMPAIGN LAB,DRUG DEV SECT,DRUG METAB TEAM,SUTTON SM2 5PX,SURREY,ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1986年 / 35卷 / 05期

关键词：

D O I：

10.1016/0006-2952(86)90251-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：827 / 834

页数：8

共 20 条

[1]

ADAM HK, 1980, CANCER TREAT REP, V64, P761

[2] METABOLISM OF TAMOXIFEN BY ISOLATED RAT HEPATOCYTES - ANTI-ESTROGENIC ACTIVITY OF TAMOXIFEN N-OXIDE [J].

BATES, DJ ;

FOSTER, AB ;

GRIGGS, LJ ;

JARMAN, M .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (17) :2823-2827

[3]

BORGNA JL, 1981, J BIOL CHEM, V256, P859

[4] METABOLISM OF TAMOXIFEN BY RAT-LIVER MICROSOMES - FORMATION OF THE N-OXIDE, A NEW METABOLITE [J].

FOSTER, AB ;

GRIGGS, LJ ;

JARMAN, M ;

VANMAANEN, JMS ;

SCHULTEN, HR .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (13) :1977-1979

[5] HYDROXY DERIVATIVES OF TAMOXIFEN [J].

FOSTER, AB ;

JARMAN, M ;

LEUNG, OT ;

MCCAGUE, R ;

LECLERCQ, G ;

DEVLEESCHOUWER, N .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (10) :1491-1497

[6] DEUTERIUM-ISOTOPE EFFECTS IN STUDIES OF DRUG-METABOLISM [J].

FOSTER, AB .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1984, 5 (12) :524-527

[7] METABOLISM OF TAMOXIFEN (ICI 46,474) .1. LABORATORY-ANIMALS [J].

FROMSON, JM ;

PEARSON, S ;

BRAMAH, S .

XENOBIOTICA, 1973, 3 (11) :693-709

[8] METABOLISM OF TAMOXIFEN (ICI 46,474) .2. FEMALE PATIENTS [J].

FROMSON, JM ;

PEARSON, S ;

BRAMAH, S .

XENOBIOTICA, 1973, 3 (11) :711-714

[9] DETERMINATION OF PROTEIN - MODIFICATION OF LOWRY METHOD THAT GIVES A LINEAR PHOTOMETRIC RESPONSE [J].

HARTREE, EF .

ANALYTICAL BIOCHEMISTRY, 1972, 48 (02) :422-&

[10] TAMOXIFEN - REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE IN TREATMENT OF BREAST-CANCER [J].

HEEL, RC ;

BROGDEN, RN ;

SPEIGHT, TM ;

AVERY, GS .

DRUGS, 1978, 16 (01) :1-24

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