THE BIOSYNTHESIS OF THE MOLD METABOLITES ROQUEFORTINE AND ASZONALENIN FROM L-[2,4,5,6,7-H-5(2)] TRYPTOPHAN

被引:17
作者
BHAT, B
HARRISON, DM
LAMONT, HM
机构
[1] UNIV ULSTER,DEPT CHEM,COLERAINE BT52 1SA,NORTH IRELAND
[2] UNIV WARWICK,DEPT CHEM,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND
关键词
D O I
10.1016/S0040-4020(01)81556-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
L-[2,4,5,6,7-H-2(5)]Tryptophan was incorporated into roquefortine 2 by Penicillium roqueforti and aszonalenin 3 by Aspergillus zonatus with retention in each case of five deuterium atoms; the 5a-hydrogen of both metabolites is derived from the 2-hydrogen of tryptophan.
引用
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页码:10663 / 10668
页数:6
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