SYNTHESIS AND BIOLOGICAL EVALUATION OF AN ALKENYLDIARYLMETHANE (ADAM) WHICH ACTS AS A NOVEL NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITOR

被引：25

作者：

CUSHMAN, M

GOLEBIEWSKI, M

BUCKHEIT, RW

GRAHAM, L

RICE, WG

机构：

[1] FREDERICK RES CTR,SO RES INST,VIROL RES GRP,FREDERICK,MD 21701

[2] NCI,FREDERICK CANC RES & DEV CTR,SAIC FREDERICK,ANTIVIRAL DRUG MECHANISMS LAB,FREDERICK,MD 21702

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 22期

关键词：

D O I：

10.1016/0960-894X(95)00465-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

ADAM, a novel non-nucleoside HIV-1 reverse transcriptase inhibitor, was synthesized and found to inhibit a variety of HIV-1 strains. In common with other known NNRTIs, ADAM is inactive against HIV-2 and it is much more active as an inhibitor of HIV-1 reverse transcriptase with poly(rC).oligo(dG) as the template/primer than it is with poly(rA).oligo(dT) as the template/primer.

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页码：2713 / 2716

页数：4

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