MOLECULAR MODELING OF THE NORRIE DISEASE PROTEIN PREDICTS A CYSTINE KNOT GROWTH-FACTOR TERTIARY STRUCTURE

被引：148

作者：

MEITINGER, T

MEINDL, A

BORK, P

ROST, B

SANDER, C

HAASEMANN, M

MURKEN, J

机构：

[1] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY

[2] MAX DELBRUCK CTR MOLEC MED,D-13122 BERLIN,GERMANY

[3] INST JACQUES MONOD,F-75251 PARIS,FRANCE

来源：

NATURE GENETICS | 1993年 / 5卷 / 04期

关键词：

D O I：

10.1038/ng1293-376

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The X-lined gene for Norrie disease, which is characterized by blindness, deafness and mental retardation has been cloned recently. This gene has been thought to code for a putative extracellular factor; its predicted amino acid sequence is homologous to the C-terminal domain of diverse extracellular proteins. Sequence pattern searches and three-dimensional modelling now suggest that the Norrie disease protein (NDP) has a tertiary structure similar to that of transforming growth factor beta (TGF beta). Our model identifies NDP as a member of an emerging family of growth factors containing a cystine knot motif, with direct implications for the physiological role of NDP. The model also sheds light on sequence related domains such as the C-terminal domain of mucins and of von Willebrand factor.

引用

页码：376 / 380

页数：5

共 42 条

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