Natural autoantibodies

被引：526

作者：

Coutinho, A

Kazatchkine, MD

Avrameas, S

机构：

[1] INST PASTEUR,UNITE IMMUNOCYTOCHIM,CNRS,URA 1961,F-75724 PARIS 15,FRANCE

[2] HOP BROUSSAIS,INSERM,U430,F-75674 PARIS 14,FRANCE

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 06期

关键词：

D O I：

10.1016/0952-7915(95)80053-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoantibodies of the IgM, IgG and IgA classes, reactive with a variety of serum proteins, cell surface structures and intracellular structures, are 'naturally' found in all normal individuals. Present in human cord blood and in 'antigen-free' mice, their variable-region repertoire is selected by antigenic structures in the body and remains conserved throughout life, Encoded by germline genes with no, or few, mutations, natural autoantibodies are characteristically 'multireactive' and do not undergo affinity maturation in normal individuals. Natural autoantibodies may participate in a variety of physiological activities, from immune regulation, homeostasis and repertoire selection, to resistance to infections, transport and functional modulation of biologically active molecules.

引用

页码：812 / 818

页数：7

共 89 条

[1] INTRAVENOUS IMMUNOGLOBULIN TREATMENT OF EXPERIMENTAL T-CELL-MEDIATED AUTOIMMUNE-DISEASE - UP-REGULATION OF T-CELL PROLIFERATION AND DOWN-REGULATION OF TUMOR-NECROSIS-FACTOR-ALPHA SECRETION [J].