IN-VIVO RADIOPROTECTIVE EFFECT OF CHLOROPHYLLIN ON SISTER-CHROMATID EXCHANGE INDUCTION IN MURINE SPERMATOGONIAL CELLS

被引：17

作者：

MORALESRAMIREZ, P

MENDIOLACRUZ, MT

机构：

[1] Instituto Nacional de Investigaciones Nucleares, CP 11010 Mexico, D.F.

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY | 1995年 / 344卷 / 1-2期

关键词：

D O I：

10.1016/0165-1218(95)90041-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The radioprotective capacity of chlorophyllin was determined by measuring the reduction of gamma-ray-induced sister chromatid exchange (SCE) in murine spermatogonia in vivo. The results obtained in experiments using 100 and 200 mu g of chlorophyllin per gram of body weight (bw) and irradiated either before or after BrdU incorporation, indicate that a chlorophyllin dose of 200 mu g/g bw protects 100% against the induction of SCE by 0.75 Gy of gamm-rays and 100 mu g/g bw protects less than 50%. Chlorophyllin per se did not have any effect on the SCE frequency.

引用

页码：73 / 78

页数：6

共 37 条

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