LIPOPHILIC CHARACTER OF CARDIAC-GLYCOSIDES - RM VALUES AS LIPOPHILICITY PARAMETERS

被引：8

作者：

BIAGI, GL

BARBARO, AM

GUERRA, MC

BOREA, PA

RECANATINI, M

机构：

[1] UNIV FERRARA,IST FARMACOL,I-44100 FERRARA,ITALY

[2] UNIV BOLOGNA,DIPARTIMENTO SCI FARMACEUT,I-40126 BOLOGNA,ITALY

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 504卷 / 01期

关键词：

D O I：

10.1016/S0021-9673(01)89522-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Chromatographic RM values were measured for a series of 41 cardiac glycosides and aglycones. By means of the ΔRM values it was possible to calculate the RM values for a further 19 compounds. An excellent correlation was found between the present RM values and those measured or calculated with the Cohnen et al. system. In a similar way, the RM values were shown to be well correlated with both high-performance liquid chromatographic data octanol-water partition coefficients (log P). The additive contribution of each substituent group to the overall lipophilicity of the molecule seems to be constant in each subset of Digitalis derivatives. © 1990.

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页码：163 / 178

页数：16

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