LIPOPHILIC CHARACTER OF CARDIAC-GLYCOSIDES - RM VALUES AS LIPOPHILICITY PARAMETERS

被引:8
作者
BIAGI, GL
BARBARO, AM
GUERRA, MC
BOREA, PA
RECANATINI, M
机构
[1] UNIV FERRARA,IST FARMACOL,I-44100 FERRARA,ITALY
[2] UNIV BOLOGNA,DIPARTIMENTO SCI FARMACEUT,I-40126 BOLOGNA,ITALY
来源
JOURNAL OF CHROMATOGRAPHY | 1990年 / 504卷 / 01期
关键词
D O I
10.1016/S0021-9673(01)89522-4
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Chromatographic RM values were measured for a series of 41 cardiac glycosides and aglycones. By means of the ΔRM values it was possible to calculate the RM values for a further 19 compounds. An excellent correlation was found between the present RM values and those measured or calculated with the Cohnen et al. system. In a similar way, the RM values were shown to be well correlated with both high-performance liquid chromatographic data octanol-water partition coefficients (log P). The additive contribution of each substituent group to the overall lipophilicity of the molecule seems to be constant in each subset of Digitalis derivatives. © 1990.
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收藏
页码:163 / 178
页数:16
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