MYELIN BASIC PROTEIN-SPECIFIC T-CELLS INDUCE DEMYELINATING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN BUFFALO RATS

被引:18
作者
JONES, RE
BOURDETTE, DN
OFFNER, H
VANDENBARK, AA
机构
[1] OREGON HLTH SCI UNIV,DEPT NEUROL,PORTLAND,OR 97201
[2] OREGON HLTH SCI UNIV,DEPT MICROBIOL & IMMUNOL,PORTLAND,OR 97201
关键词
(Buffalo rat); Demyelination; Experimental autoimmune encephalomyelitis; Passive immunization;
D O I
10.1016/0165-5728(90)90053-P
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses. © 1990.
引用
收藏
页码:61 / 69
页数:9
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