GENTAMICIN INTERVAL IN NEWBORN-INFANTS AS DETERMINED BY RENAL-FUNCTION AND POSTCONCEPTIONAL AGE

被引：24

作者：

BRION, LP

FLEISCHMAN, AR

SCHWARTZ, GJ

机构：

[1] Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine and Montefiere Medical Center, Bronx, 10461, New York, Room 8S7, Pelham parkway South and Eastchester Road

[2] Division of Nephrology, Department of Pediatrics, Albert Einstein College of Medicine and Montefiere Medical Center, Bronx, 10461, New York, Room 8S7, Pelham parkway South and Eastchester Road

来源：

PEDIATRIC NEPHROLOGY | 1991年 / 5卷 / 06期

关键词：

GENTAMICIN; NEWBORN; ACUTE RENAL FAILURE; PHARMACOKINETICS; PLASMA CREATININE; CREATININE CLEARANCE; GLOMERULAR FILTRATION RATE;

D O I：

10.1007/BF00857868

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We evaluated the relationship between gentamicin pharmacokinetics and glomerular filtration rate in newborn infants to estimate the appropriate interval of administration in neonates with renal insufficiency. Gentamicin half-life (Gt1/2) could be predicted from plasma creatinine concentration (P(Cr)) (r = 0.78); the prediction was minimally but significantly increased (r = 0.81) by adding postconceptional age to a multiple regression analysis. Infants with a postconceptional age of 29 weeks or more and a P(Cr) of 1 mg/dl or more had significantly greater trough and peak gentamicin levels than those with a P(Cr) less than 1 mg/dl. If gentamicin is indicated in a patient with renal insufficiency, the interval of administration should be 2-3 Gt1/2, which can be estimated from P(Cr) (Gt1/2 = 2.0 + 7.7 P(Cr)). The interval can then be adjusted according to peak and trough gentamicin levels.

引用

页码：675 / 679

页数：5

共 31 条

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