THE RELATIONSHIP BETWEEN DEVELOPMENT OF LUNG INFLAMMATION AND CHANGES IN BONE-MARROW POPULATIONS IN GUINEA-PIGS FOLLOWING INHALED ANTIGEN CHALLENGE

被引：12

作者：

BARTON, HJ ^{[1
]}

BOND, A ^{[1
]}

BOOT, JR ^{[1
]}

BRANDON, DR ^{[1
]}

OBRIEN, A ^{[1
]}

机构：

[1] ELI LILLY & CO LTD,LILLY RES CTR LTD,ERL WOOD MANOR,WINDLESHAM GU20 6PH,SURREY,ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 96卷 / 01期

关键词：

D O I：

10.1159/000235527

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Sensitised guinea-pigs were exposed to aerosolised antigen. The resultant cellular infiltration into the lung was assessed in lung tissue and bronchoalveolar lavage fluid 6, 24, 72 h and 7 days later. An early neutrophil infiltration peaking at 6 h was succeeded by eosinophil migration which persisted for 7 days, at which time some of the eosinophils appeared immature. The lung eosinophilia was accompanied by an initial fall in eosinophilic cells in the bone marrow, followed by an increase in this population. Treatment with dexamethasone (25 mg/kg i.p.) given daily for 7 days after antigen challenge reduced the lung eosinophilia and observed bone marrow changes.

引用

页码：1 / 11

页数：11

共 22 条

[1] ALLERGEN-INDUCED INCREASE IN BRONCHIAL RESPONSIVENESS TO HISTAMINE - RELATIONSHIP TO THE LATE ASTHMATIC RESPONSE AND CHANGE IN AIRWAY CALIBER [J].

CARTIER, A ;

THOMSON, NC ;

FRITH, PA ;

ROBERTS, R ;

HARGREAVE, FE .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1982, 70 (03) :170-177

[2]

CLUTTERBUCK EJ, 1989, BLOOD, V73, P1504

[3] ALLERGEN-INDUCED INCREASE IN NONALLERGIC BRONCHIAL REACTIVITY [J].

COCKCROFT, DW ;

RUFFIN, RE ;

DOLOVICH, J ;

HARGREAVE, FE .

CLINICAL ALLERGY, 1977, 7 (06) :503-513

[4]

DEMONCHY JGR, 1985, AM REV RESPIR DIS, V131, P373

[5] DEVELOPMENT OF A PROLONGED EOSINOPHIL-RICH INFLAMMATORY LEUKOCYTE INFILTRATION IN THE GUINEA-PIG ASTHMATIC RESPONSE TO OVALBUMIN INHALATION [J].

DUNN, CJ ;

ELLIOTT, GA ;

OOSTVEEN, JA ;

RICHARDS, IM .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (03) :541-547

[6] MODULATION BY DRUGS OF EOSINOPHIL RECRUITMENT INDUCED BY IMMUNE CHALLENGE IN THE RAT - POSSIBLE ROLES OF INTERLEUKIN-5 AND PLATELET-ACTIVATING FACTOR [J].

ETIENNE, A ;

SOULARD, C ;

THONIER, F ;

BRAQUET, P .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1989, 88 (1-2) :216-221

[7]

FRIGAS E, 1980, LAB INVEST, V42, P35

[8] CHANGES IN LYMPHOCYTE-T SUBPOPULATIONS AFTER ANTIGENIC BRONCHIAL PROVOCATION IN ASTHMATICS [J].

GERBLICH, AA ;

CAMPBELL, AE ;

SCHUYLER, MR .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (21) :1349-1352

[9]

GILLIS S, 1979, J IMMUNOL, V123, P1624

[10]

GILLIS S, 1979, J IMMUNOL, V123, P1632

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