CYCLIC SULFOLANES AS NOVEL AND HIGH-AFFINITY P-2 LIGANDS FOR HIV-1 PROTEASE INHIBITORS

被引:40
作者
GHOSH, AK
THOMPSON, WJ
LEE, HY
MCKEE, SP
MUNSON, PM
DUONG, TT
DARKE, PL
ZUGAY, JA
EMINI, EA
SCHLEIF, WA
HUFF, JR
ANDERSON, PS
机构
[1] MERCK RES LABS,DEPT MOLEC BIOL,W POINT,PA 19486
[2] MERCK RES LABS,DEPT VIRUS & CELL BIOL,W POINT,PA 19486
关键词
D O I
10.1021/jm00059a019
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:924 / 927
页数:4
相关论文
共 14 条
[1]  
CRAIG JC, 1991, ANTIVIRAL RES
[2]   ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID, A VERSATILE REAGENT FOR DETERMINATION OF ENANTIOMERIC COMPOSITION OF ALCOHOLS AND AMINES [J].
DALE, JA ;
DULL, DL ;
MOSHER, HS .
JOURNAL OF ORGANIC CHEMISTRY, 1969, 34 (09) :2543-&
[3]  
DARKE PL, 1989, J BIOL CHEM, V264, P2307
[4]   CATALYTIC ASYMMETRIC EPOXIDATION AND KINETIC RESOLUTION - MODIFIED PROCEDURES INCLUDING INSITU DERIVATIZATION [J].
GAO, Y ;
HANSON, RM ;
KLUNDER, JM ;
KO, SY ;
MASAMUNE, H ;
SHARPLESS, KB .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (19) :5765-5780
[5]   N,N'-DISUCCINIMIDYL CARBONATE - A USEFUL REAGENT FOR ALKOXYCARBONYLATION OF AMINES [J].
GHOSH, AK ;
DUONG, TT ;
MCKEE, SP ;
THOMPSON, WJ .
TETRAHEDRON LETTERS, 1992, 33 (20) :2781-2784
[6]   DI(2-PYRIDYL) CARBONATE PROMOTED ALKOXYCARBONYLATION OF AMINES - A CONVENIENT SYNTHESIS OF FUNCTIONALIZED CARBAMATES [J].
GHOSH, AK ;
DUONG, TT ;
MCKEE, SP .
TETRAHEDRON LETTERS, 1991, 32 (34) :4251-4254
[7]   3-TETRAHYDROFURAN AND PYRAN URETHANES AS HIGH-AFFINITY P2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS [J].
GHOSH, AK ;
THOMPSON, WJ ;
MCKEE, SP ;
DUONG, TT ;
LYLE, TA ;
CHEN, JC ;
DARKE, PL ;
ZUGAY, JA ;
EMINI, EA ;
SCHLEIF, WA ;
HUFF, JR ;
ANDERSON, PS .
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (02) :292-294
[8]   AFFINITY PURIFICATION OF THE HIV-1 PROTEASE [J].
HEIMBACH, JC ;
GARSKY, VM ;
MICHELSON, SR ;
DIXON, RAF ;
SIGAL, IS ;
DARKE, PL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (03) :955-960
[9]  
MARTIN JA, 1990, Patent No. 432695
[10]   PHEROMONE SYNTHESIS .24. SYNTHESIS OF OPTICALLY-ACTIVE FORMS OF IPSDIENOL AND IPSENOL - PHEROMONE COMPONENTS OF IPS BARK BEETLES [J].
MORI, K ;
TAKIGAWA, T ;
MATSUO, T .
TETRAHEDRON, 1979, 35 (08) :933-940