BRAIN PROTEIN-KINASE PK40(ERK) CONVERTS TAU INTO A PHF-LIKE FORM AS FOUND IN ALZHEIMERS-DISEASE

被引：116

作者：

RODER, HM

EDEN, PA

INGRAM, VM

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

[2] MILES INC,W HAVEN,CT 06516

[3] BIOMEASURES INC,MILFORD,MA 01757

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 193卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1672

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The novel protein kinase PK40 (1) was characterized by its ability to phosphorylate Lys-Ser-Pro sites in neurofilament and TAU proteins. PK40 is now recognized to be a member of the family of External-stimulus Regulated Kinases (ERKs) by its reactivity with ERK-specific antibodies and will therefore be called PK40erk. Bovine TAU or recombinant human TAU proteins can be hyper-phosphorylated by PK40erk to produce the electrophoretic mobility shifts and certain iminunochemical properties characteristic of PHF-TAU isolated from Alzheimer′s disease brain tissue. PK40erk may play a crucial role in the etiology of this disease. © 1993 Academic Press. All rights reserved.

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页码：639 / 647

页数：9

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