SIMPLE AND VERSATILE SYNTHESIS OF OPTICALLY-ACTIVE 1,2-AMINO ALCOHOLS BY GRIGNARD ADDITION TO N,O-DIBENZYLGLYCERALDIMINE AND N,O-LACTALDIMINE

被引：44

作者：

FRANZ, T

HEIN, M

VEITH, U

JAGER, V

PETERS, EM

PETERS, K

VONSCHNERING, HG

机构：

[1] UNIV WURZBURG,INST ORGAN CHEM,D-97074 WURZBURG,GERMANY

[2] MAX PLANCK INST FESTKORPERFORSCH,W-7000 STUTTGART,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 12期

关键词：

D O I：

10.1002/anie.199412981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In many cases with high threo selectivity, Grignard additions can be performed on simple, nonactivated, and even enolizable imine derivatives of optically active aldehydes, as the reactions with 1 and 2 show. This should open a new route to aminohydroxy acids that supplements the familiar one starting from α‐amino acids/aldehydes. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

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页码：1298 / 1301

页数：4

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