DETERMINATION OF IMPURITIES IN A NOVEL ANALOG OF ADENOSINE 5'-TRIPHOSPHATE BY CAPILLARY ELECTROPHORESIS

被引：8

作者：

DAWSON, JR ^{[1
]}

NICHOLS, SC ^{[1
]}

TAYLOR, GE ^{[1
]}

机构：

[1] FISONS PLC,DEPT ANALYT CHEM,DIV PHARMACEUT,RES & DEV LABS,LOUGHBOROUGH LE11 0RH,LEICS,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY A | 1995年 / 700卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(95)00055-R

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A capillary electrophoretic method using an uncoated capillary was developed to resolve potential impurities in FPL 67085XX, a novel phosphonate analogue of adenosine 5'-triphosphate. The effects of buffers, buffer concentration, eluent pH and methanol were investigated. Optimum resolution of the impurities was achieved using an eluent consisting of 7% (v/v) methanol in 25 mM phosphate buffer-2 mM EDTA adjusted to pH 6.6.

引用

页码：163 / 172

页数：10

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