A FUNDAMENTAL DIVISION IN THE ALU FAMILY OF REPEATED SEQUENCES

被引：379

作者：

JURKA, J ^{[1
]}

SMITH, T ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, SCH PUBL HLTH, DANA FARBER CANC INST, BOSTON, MA 02115 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1988年 / 85卷 / 13期

关键词：

D O I：

10.1073/pnas.85.13.4775

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Alu family of repeated sequences from the human genome contains two distinct subfamilies. This division is based on different base preferences in a number of diagnostic sequence positions. One subfamily of the sequences, referred to as the Alu-J subfamily, is very similar to 7SL DNA in these positions. The other subfamily, Alu-S, can be divided further into well-defined branches of sequences. These findings revise the previous picture of the Alu family and expose their complex evolutionary dynamics. They reveal sequence variations of potential importance for the proliferation of Alu repeats and relate them to their structural features. In addition, they open the possibility of using different types of Alu sequences as natural markers for studying genetic rearrangements in the genome.

引用

页码：4775 / 4778

页数：4

共 14 条

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