REGION-SPECIFIC INHIBITION OF POTASSIUM-EVOKED [H-3] NORADRENALINE RELEASE FROM RAT-BRAIN SYNAPTOSOMES BY NEUROPEPTIDE Y-(13-36) - INVOLVEMENT OF NPY-RECEPTORS OF THE Y2-TYPE

被引：37

作者：

MARTIRE, M

PISTRITTO, G

MORES, N

AGNATI, LF

FUXE, K

机构：

[1] KAROLINSKA INST, DEPT HISTOL & NEUROBIOL, S-10401 STOCKHOLM 60, SWEDEN

[2] UNIV MODENA, DEPT HUMAN PHYSIOL, I-41100 MODENA, ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 230卷 / 02期

关键词：

NPY-RECEPTORS; BRAIN; TERMINALS; H-3]NORADRENALINE RELEASE; (RAT);

D O I：

10.1016/0014-2999(93)90807-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of the Y2 receptor agonist neuropeptide Y NPY-(13-36) on the depolarization-evoked release of [H-3]noradrenaline (NA) from synaptosomal preparations of the medulla oblongata, the hypothalamus, the hippocampal formation and the parieto-occipital cortex of the male rat were studied. NPY-(13-36) (0.1-100 nM) caused a concentration-related inhibition of the depolarization-induced release of [H-3]NA in all areas studied, except the parieto-occipital cortex. The results indicate that NPY Y2 receptors are present on NA terminals in all areas studied, except the parieto-occipital cortex and inhibit depolarization-evoked [H-3]NA release.

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收藏

页码：231 / 234

页数：4

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