FENFLURAMINES APPETITE SUPPRESSION AND SEROTONIN NEUROTOXICITY ARE SEPARABLE

被引：14

作者：

MCCANN, UD

YUAN, J

RICAURTE, GA

机构：

[1] NIMH,BIOL PSYCHIAT BRANCH,ANXIETY & AFFECT DISORDERS SECT,BETHESDA,MD 20892

[2] JOHNS HOPKINS MED INST,DEPT NEUROL,BALTIMORE,MD 21224

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 283卷 / 1-3期

关键词：

FENFLURAMINE; NEUROTOXICITY; APPETITE;

D O I：

10.1016/0014-2999(95)00482-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To determine whether fenfluramine's anorectic and neurotoxic effects could be dissociated, rats were treated with fenfluramine or the serotonin transporter blocker fluoxetine, alone or in combination. Fenfluramine alone produced anorexia, weight loss and lasting depletions of brain serotonin axon markers. Fluoxetine prevented fenfluramine-induced long-term serotonergic deficits, yet did not diminish fenfluramine's acute anorectic effects. These findings indicate that fenfluramine's anorectic and neurotoxic actions are distinct and separable.

引用

页码：R5 / R7

页数：3

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