THE FILLING OF MOLTEN IBUPROFEN INTO HARD GELATIN CAPSULES

被引：12

作者：

SMITH, A

LAMPARD, JF

CARRUTHERS, KM

REGAN, P

机构：

[1] Pharmaceutical Division, The Boots Company PLC, Nottingham

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 59卷 / 02期

关键词：

Dissolution rate; Ibuprofen; Melt-filled capsule; Rheological properties;

D O I：

10.1016/0378-5173(90)90085-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The dissolution rate of melt-filled ibuprofen capsules is markedly affected by low (10% or less) levels of a variety of excipients. Thus, a high fill weight can be achieved and virtually any in vitro dissolution profile obtained. For any particular system of interest the effect of processing conditions can be readily determined. © 1990.

引用

页码：115 / 119

页数：5

共 11 条

[1]

BLOCH DW, 1987, PHARM ACTA HELV, V62, P23

[2]

BOWTLE WJ, 1988, PHARM TECHNOL JUN, P86

[3] ABSORPTION CHARACTERISTICS OF SOLID DISPERSED AND MICRONIZED GRISEOFULVIN IN MAN [J].