ROLE OF OXYGEN RADICALS IN TOURNIQUET-RELATED ISCHEMIA-REPERFUSION INJURY OF HUMAN PATIENTS

被引：45

作者：

FRIEDL, HP ^{[1
]}

TILL, GO ^{[1
]}

TRENTZ, O ^{[1
]}

WARD, PA ^{[1
]}

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48104

来源：

KLINISCHE WOCHENSCHRIFT | 1991年 / 69卷 / 21-23期

关键词：

XANTHINE OXIDASE; TOURNIQUET; REPERFUSION INJURY;

D O I：

10.1007/BF01645168

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the current study we evaluated effluent blood from extremities of human patients undergoing reconstructive surgical treatment which is routinely accompanied by upper extremity exsanguination and application of a tourniquet. Following tourniquet release (reperfusion), there were immediate increases in the plasma levels of xanthine oxidase activity, uric acid, and histamine. Xanthine dehydrogenase activity was not detectable. Plasma also contained products consistent with the formation of oxygen-derived free radicals, namely hemoglobin and fluorescent compounds. Our data indicate in humans that ischemia-reperfusion events are associated with the appearance of xanthine oxidase activity and it's products in the plasma effluent.

引用

页码：1109 / 1112

页数：4

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