PRENATAL COCAINE EXPOSURE - DECREASED SENSITIZATION TO COCAINE AND DECREASED STRIATAL DOPAMINE TRANSPORTER BINDING IN OFFSPRING

被引：48

作者：

BYRNES, JJ ^{[1
]}

PRITCHARD, GA ^{[1
]}

KOFF, JM ^{[1
]}

MILLER, LG ^{[1
]}

机构：

[1] TUFTS UNIV, SCH MED, DEPT PHARMACOL & EXPTL THERAPEUT, BOSTON, MA 02111 USA

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 07期

关键词：

COCAINE; PRENATAL; DOPAMINE TRANSPORTER; DOPAMINE;

D O I：

10.1016/0028-3908(93)90087-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pregnant mice were treated with cocaine, 10 mg/kg/day, during days 13 to 20 of gestation. Cocaine sensitization and dopamine transporter binding were evaluated in offspring at 6 weeks of age. Sensitization, defined as the increase in activity after 5 injections of cocaine compared to 1 injection, was reduced in cocaine-exposed mice. Dopamine transporter binding in striatum was also significantly reduced in cocaine-exposed mice compared to controls.

引用

页码：721 / 723

页数：3

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