(R)-(+)-3-AMINO-2-PHENYLPROPANOIC ACID - A REVISED ABSOLUTE-CONFIGURATION BASED ON AN ENANTIOSELECTIVE SYNTHESIS AND AN X-RAY CRYSTAL-STRUCTURE OF THE SALT WITH (1S)-(+)-CAMPHOR-10-SULFONIC ACID

被引:21
作者
DSOUZA, AA
MOTEVALLI, M
ROBINSON, AJ
WYATT, PB
机构
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 01期
关键词
D O I
10.1039/p19950000001
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Amidoalkylation of the lithium enolate of (4S,5R)-4-methyl-5-phenyl-3-(phenylacetyl) oxazolidin-2-one 5 by 1-(N-benzyloxycarbonylaminomethyl)benxotriazole 2c, followed by cleavage of the oxazolidinone chiral auxiliary and of the N-benzyloxycarbonyl group, gave (R)-(+)-3-amino-2-phenylpropanoic acid 1, the absolute configuration of which was determined by X-ray crystallography on the salt 8 with (1S)-(+)-camphor-10-sulfonic acid.
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页码:1 / 2
页数:2
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