SELECTION OF NEW BIOLOGICAL-ACTIVITIES FROM RANDOM NUCLEOTIDE-SEQUENCES - EVOLUTIONARY AND PRACTICAL CONSIDERATIONS

被引:12
作者
HORWITZ, MSZ [1 ]
DUBE, DK [1 ]
LOEB, LA [1 ]
机构
[1] UNIV WASHINGTON,DEPT PATHOL,JOSEPH GOTTSTEIN MEM CANC RES LAB,SM-30,SEATTLE,WA 98195
关键词
D O I
10.1139/g89-021
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:112 / 117
页数:6
相关论文
共 16 条
[2]   RNA AS AN RNA-POLYMERASE - NET ELONGATION OF AN RNA PRIMER CATALYZED BY THE TETRAHYMENA RIBOZYME [J].
BEEN, MD ;
CECH, TR .
SCIENCE, 1988, 239 (4846) :1412-1416
[3]   HYPERCYCLE - PRINCIPLE OF NATURAL SELF-ORGANIZATION .A. EMERGENCE OF HYPERCYCLE [J].
EIGEN, M ;
SCHUSTER, P .
NATURWISSENSCHAFTEN, 1977, 64 (11) :541-565
[4]  
HORWITZ MSZ, 1988, J BIOL CHEM, V263, P14724
[5]   PROMOTERS SELECTED FROM RANDOM DNA-SEQUENCES [J].
HORWITZ, MSZ ;
LOEB, LA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7405-7409
[6]   MANY RANDOM SEQUENCES FUNCTIONALLY REPLACE THE SECRETION SIGNAL SEQUENCE OF YEAST INVERTASE [J].
KAISER, CA ;
PREUSS, D ;
GRISAFI, P ;
BOTSTEIN, D .
SCIENCE, 1987, 235 (4786) :312-317
[7]   APURINIC SITES AS MUTAGENIC INTERMEDIATES [J].
LOEB, LA .
CELL, 1985, 40 (03) :483-484
[8]   A NEW CLASS OF YEAST TRANSCRIPTIONAL ACTIVATORS [J].
MA, J ;
PTASHNE, M .
CELL, 1987, 51 (01) :113-119
[9]   HYDROPHOBIC STABILIZATION IN T4 LYSOZYME DETERMINED DIRECTLY BY MULTIPLE SUBSTITUTIONS OF ILE-3 [J].
MATSUMURA, M ;
BECKTEL, WJ ;
MATTHEWS, BW .
NATURE, 1988, 334 (6181) :406-410
[10]  
OLIPHANT AR, 1987, METHOD ENZYMOL, V155, P568