5-HYDROXYTRYPTAMINE AMPLIFIES BETA-ADRENERGIC STIMULATION OF N-ACETYLTRANSFERASE ACTIVITY IN RAT PINEALOCYTES

被引：29

作者：

SUGDEN, D

机构：

[1] Biomedical Sciences Division, King's College London, London

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 05期

关键词：

5‐Hydroxytryptamine; N‐Acetyltransferase; Pinealocytes; β‐Adrenergic;

D O I：

10.1111/j.1471-4159.1990.tb04952.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract: In cultured rat pinealocytes β‐adrenergic induction of N‐acetyltransferase, a key enzyme in the synthesis of melatonin, is amplified by addition of 5‐hydroxytryptamine (5‐HT) to the culture medium. However, 5‐HT when added alone has no effect on enzyme activity. Pharmacological experiments with a range of agonists and antagonists suggest that this action is not mediated by 5‐HT1, 5‐HT2, 5‐HT3, or 5‐HT4 receptor subtypes but may involve a site similar to the 5‐HTip receptor described in the enteric nervous system. The potential role of 5‐HT in modulating adrenergic stimulation of N‐acetyltransferase activity is discussed. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1655 / 1658

页数：4

共 22 条

[1] NORADRENERGIC STIMULATION OF SEROTONIN RELEASE FROM RAT PINEAL GLANDS INVITRO [J].