RAPID SENSITIZATION TO THE CARDIOVASCULAR EFFECTS OF COCAINE IN RATS

被引：21

作者：

TELLA, SR

SCHINDLER, CW

GOLDBERG, SR

机构：

[1] GEORGETOWN UNIV,SCH MED,DEPT PHARMACOL,WASHINGTON,DC 20007

[2] UNIV MARYLAND,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 194卷 / 01期

关键词：

COCAINE; BLOOD PRESSURE; HEART RATE; SENSITIZATION; CARDIOVASCULAR TOXICITY; (RAT);

D O I：

10.1016/0014-2999(91)90133-B

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effects of repeated daily administrations of cocaine on blood pressure and heart rate were studied in conscious rats. Cocaine (0.03-3.0 mg/kg i.v.) increased blood pressure and heart rate the first time it was administered (day 1) However, the magnitude and duration of the increases in blood pressure caused by cocaine (0.1-3.0 mg/kg) dramatically increased on day 2 and remained (except 1.0 mg/kg dose) at these levels through day 5. Following two drug-free days (days 6 and 7), the increase in blood pressure caused by cocaine (0.1, 0.3 and 3.0 mg/kg) on day 8 was still elevated. Unlike blood pressure, no enhancement in heart rate response to cocaine was observed.

引用

页码：119 / 122

页数：4

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