ANTAGONISTS OF THE NMDA RECEPTOR AND ALLOPURINOL PROTECT THE OLFACTORY CORTEX BUT NOT THE STRIATUM AFTER INTRACEREBRAL INJECTION OF KAINIC ACID

被引：20

作者：

FACCHINETTI, F ^{[1
]}

VIRGILI, M ^{[1
]}

CONTESTABILE, A ^{[1
]}

BARNABEI, O ^{[1
]}

机构：

[1] UNIV BOLOGNA,DEPT BIOL,VIA BELMELORO 8,I-40126 BOLOGNA,ITALY

来源：

BRAIN RESEARCH | 1992年 / 585卷 / 1-2期

关键词：

EXCITOTOXICITY; FREE RADICAL; N-METHYL-D-ASPARTIC ACID (NMDA) RECEPTOR; STRIATUM; OLFACTORY CORTEX;

D O I：

10.1016/0006-8993(92)91231-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Overstimulation of the NMDA receptor, as well as generation of excessive amounts of free radicals, has been implicated in excitotoxic brain injuries. We report here that two antagonists of the NMDA receptor and an inhibitor of the free radical-generating enzyme, xanthine oxidase. protect the olfactory cortex but not the striatum after intrastriatal injection of kainic acid. Our results suggest the existence of a precise link between excitotoxic activation of the NMDA receptor and neuropathology related to excessive amounts of free radicals. The focal point of this link may be the entry of Ca2+ through the NMDA receptor and the consequent activation of proteases and free radical-generating systems.

引用

页码：330 / 334

页数：5

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