P53 POINT MUTATIONS IN PRIMARY HUMAN GASTRIC CARCINOMAS

被引：83

作者：

YOKOZAKI, H ^{[1
]}

KUNIYASU, H ^{[1
]}

KITADAI, Y ^{[1
]}

NISHIMURA, K ^{[1
]}

TODO, H ^{[1
]}

AYHAN, A ^{[1
]}

YASUI, W ^{[1
]}

ITO, H ^{[1
]}

TAHARA, E ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT PATHOL,1-2-3 KASUMI,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1992年 / 119卷 / 02期

关键词：

P53; GENE; GASTRIC CARCINOMA; POINT MUTATION; POLYMERASE CHAIN REACTION; DEOXYNUCLEOTIDE SEQUENCING;

D O I：

10.1007/BF01209657

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

p53 point mutations in primary gastric carcinomas were analyzed by performing cDNA deoxynucleotide sequencing of the gene. Out of 16,9 (56.3%) primary gastric carcinoma cases, including early cancer, showed one or more p53 point mutations in their open-reading frame, and 4 out of 9 cases had a p53 point mutation within highly conserved domains. The characteristics of the p53 mutation spectrum observed in primary tumors were (a) frequent mutation at an A:T pair (50%, 7 out of 14 mutations), (b) high transversion incidence (29%, 4 out of 14 mutations), (c) no transition at CpG, and (d) no G:C to T:A transversion. Our results suggest that p53 mutation is a common event in gastric carcinoma occurring from the early stage of progression with its specific mutation spectrum.

引用

页码：67 / 70

页数：4

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