METABOLISM OF PHENYL AND ALKYL SPIN ADDUCTS OF PBN IN RAT HEPATOCYTES - RATE DEPENDENCE ON SIZE AND TYPE OF ADDEND GROUP

被引：1

作者：

JANZEN, EG

ZHDANOV, RI

REINKE, LA

机构：

[1] NPO BIOTEKHNOLOGIYA,INST BIOTECHNOL,MOSCOW 117246,RUSSIA

[2] UNIV OKLAHOMA,HLTH SCI CTR,HLTH SCI CTR,DEPT PHARMACOL,OKLAHOMA CITY,OK 73190

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1993年 / 19卷

关键词：

ALPHA-PHENYL-N-TERT-BUTYL-NITRONE; PBN; EPR; SPIN ADDUCT; SPIN LABELING; HEPATOCYTE; METABOLISM;

D O I：

10.3109/10715769309056s157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The decay of the EPR signal of phenyl and alkyl spin adducts of PBN has been monitored in rat hepatocytes. The rate of decay depends on the length of the hydrocarbon chain as follows: n-hexyl > n-dodecyl > n-octadecyl. The rate of signal decay is faster in the membrane phase than in the aqueous phase for the phenyl spin adduct.

引用

页码：S157 / S162

页数：6

共 22 条

[1] THE PRODUCTS OF THE REDUCTION OF DOXYL STEARATES IN CELLS ARE HYDROXYLAMINES AS SHOWN BY OXIDATION BY N-15-PERDEUTERATED TEMPONE [J].