ANALYSIS OF 133 MEIOSES PLACES THE GENES FOR NEVOID BASAL-CELL CARCINOMA (GORLIN)-SYNDROME AND FANCONI-ANEMIA GROUP-C IN A 2.6-CM INTERVAL AND CONTRIBUTES TO THE FINE MAP OF 9Q22.3

被引：32

作者：

FARNDON, PA

MORRIS, DJ

HARDY, C

MCCONVILLE, CM

WEISSENBACH, J

KILPATRICK, MW

REIS, A

机构：

[1] FREE UNIV BERLIN,INST HUMAN GENET,D-14059 BERLIN,GERMANY

[2] UNIV BIRMINGHAM,DEPT CANC STUDIES,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[3] GENETHON,F-91002 EVRY,FRANCE

来源：

GENOMICS | 1994年 / 23卷 / 02期

关键词：

D O I：

10.1006/geno.1994.1528

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four disease genes (NBCCS, ESS1, XPAC, FACC) map to 9q22.3-q31. A fine map of this region was produced by linkage and haplotype analysis using 12 DNA markers. The gene for nevoid basal cell carcinoma syndrome (NBCCS, Gorlin) has an important role in congenital malformations and carcinogenesis. Phase-known recombinants in a study of 133 meioses place NBCCS between (D9S12/D9S151) and D9S176. Haplotype analysis in a two-generation family suggests that NBCCS lies in a smaller interval of 2.6 cM centromeric to D9S287. These flanking markers will be useful clinically for gene tracking. Recombinants also map FACC (Fanconi anemia, group C) to the same region, between (D9S196/D9S197) and D9S287. The recombination rate between (D9S12/D9S151) and D9S53 in males is 8.3% and 13.2% in females, giving a sex-specific male:female ratio of 1:1.6 and a sex-averaged map distance of 10.4 cM. No double recombinants were detected, in agreement with the apparently complete level of interference predicted from the male chiasmata map. (C) 1994 Academic Press, Inc.

引用

页码：486 / 489

页数：4

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