SYNTHESIS OF GLUTAMATE AGONISTS AND ANTAGONISTS BY A RING SWITCHING STRATEGY

被引：39

作者：

DINSMORE, A ^{[1
]}

DOYLE, PM ^{[1
]}

YOUNG, DW ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 41期

关键词：

D O I：

10.1016/0040-4039(95)01517-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Our ring switching strategy for synthesis of compounds with structural features consistent with activity at glutamate receptors has been modified to prepare L-alanine derivatives substituted at the beta-carbon atom with six-membered heteroaromatic rings. The pyrimidinone (11, R = R(1) = R(2) = H) has been shown to be a glutamate agonist and the compound (13) to be an antagonist.

引用

页码：7503 / 7506

页数：4

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