NMDA REDOX SITE MODULATES LONG-TERM POTENTIATION OF NMDA BUT NOT OF AMPA RECEPTORS

被引：17

作者：

GOZLAN, H

CHINESTRA, P

DIABIRA, D

BENARI, Y

机构：

[1] INSERM U-29, Hôspital de Port-Royal, 75014 Paris, 123, Boulevard de Port-Royal

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 262卷 / 1-2期

关键词：

REDOX; NMDA RECEPTOR; LONG-TERM POTENTIATION;

D O I：

10.1016/0014-2999(94)90049-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have compared the effects of redox drugs on long-term potentiation mediated by AMPA or NMDA receptors. A reducing and an oxidizing agent had no effect on long-term potentiation mediated by AMPA receptors. In contrast, the induction of long-term potentiation mediated by NMDA receptors was prevented by a thiol oxidizing drug and restored by a disulfide reducing agent.

引用

页码：R3 / R4

页数：2

共 6 条

[1] THE RELATIVE CONTRIBUTION OF NMDA RECEPTOR CHANNELS IN THE EXPRESSION OF LONG-TERM POTENTIATION IN THE HIPPOCAMPAL CA1 REGION [J].