PROPERTIES OF ENZYMES .24. EFFECTS OF PARAQUAT ON PEROXIDE METABOLISM ENZYMES AND LIPID-PEROXIDATION IN THE RAT

被引：10

作者：

BARABAS, K

SZABO, L

MATKOVICS, B

BERENCSI, G

机构：

[1] ATTILA JOZSEF UNIV, BIOL ISOTOPE LAB, H-6701 SZEGED, HUNGARY

[2] ATTILA JOZSEF UNIV, SCH MED, DEPT PUBL HLTH & HYG, H-6701 SZEGED, HUNGARY

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1984年 / 15卷 / 02期

关键词：

D O I：

10.1016/0306-3623(84)90095-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

How the LD50 and L100 of PQ influence the peroxide metabolism enzymes and lipid peroxidation in organ homogenates and blood samples of the rat was studied. The peroxide metabolism enzyme activities were changed in a concentration dependent manner. In general, the lower doses of PQ increased superoxide dismutase [EC 1.15.1.1], catalse [EC 1.11.1.6] activites and lipid peroxidation. The glutathione peroxidase [EC 1.11.1.9] activity was decreased. Higher doses of PQ enhanced all of the enzyme activities and lipid peroxidation.

引用

页码：133 / 137

页数：5

共 16 条

[1] PROPERTIES OF ENZYMES .23. STUDY OF THE EFFECTS OF PARAQUAT ON THE PEROXIDE METABOLISM ENZYMES IN GUINEA-PIG [J].

BARABAS, K ;

SZABO, L ;

VARGA, SI ;

BERENCSI, G ;

BARTKOWIAK, A ;

MATKOVICS, B .

GENERAL PHARMACOLOGY, 1982, 13 (02) :133-137

[2]

Beauchamp C., 1971, ANAL BIOCHEM, V44, P276, DOI DOI 10.1016/0003-2697(71)90370-8

[3]

BEERS RF, 1952, J BIOL CHEM, V195, P133

[4] MECHANISM OF PARAQUAT TOXICITY IN MICE AND RATS [J].

BUS, JS ;

CAGEN, SZ ;

OLGAARD, M ;

GIBSON, JE .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1976, 35 (03) :501-513

[5] PURIFICATION AND PROPERTIES OF RAT LUNG SOLUBLE GLUTATHIONE PEROXIDASE [J].

CHIU, DTY ;

STULTS, FH ;

TAPPEL, AL .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 445 (03) :558-566

[6]

HASSAN HM, 1977, J BIOL CHEM, V252, P7667

[7]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[8] COMPARATIVE-STUDY OF SOME MORE IMPORTANT EXPERIMENTAL ANIMAL PEROXIDE METABOLISM ENZYMES [J].

MATKOVICS, B ;

NOVAK, R ;

HANH, HD ;

SZABO, L ;

VARGA, SI ;

ZALESNA, G .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1977, 56 (01) :31-34

[9] INVIVO EFFECTS OF PARAQUAT ON SOME OXIDATIVE-ENZYMES OF MICE [J].

MATKOVICS, B ;

SZABO, L ;

VARGA, SI ;

NOVAK, R ;

BARABAS, K ;

BERENCSI, G .

GENERAL PHARMACOLOGY, 1980, 11 (03) :267-270

[10]

MATKOVICS B, 1983, GEN PHARMAC

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