THE ROLE OF THYMIC EPITHELIUM IN THE ACQUISITION OF TOLERANCE

被引：36

作者：

HOUSSAINT, E ^{[1
]}

FLAJNIK, M ^{[1
]}

机构：

[1] UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33101

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 10期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0167-5699(90)90141-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There are two separate mechanisms of induction of T-cell tolerance in the thymus. First, MHC molecules expressed on bone-marrow-derived cells can cause clonal deletion of auto-reactive cells. Second, as discussed here by Elizabeth Houssaint and Martin Flajnik, thymic epithelial cells can generate a form of tolerance that does not eliminate self-reactive clones. This non-deletional mechanism, which is also a feature of the other MHC class-II-bearing epithelia, may contribute to the establishment of tolerance-maintaining regulatory networks. © 1990.

引用

页码：357 / 360

页数：4

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