EFFECTS OF CALCIUM-BLOCKADE AND CONVERTING-ENZYME INHIBITION ON REGIONAL BLOOD-FLOW IN A CONSCIOUS RAT MODEL OF HEART-FAILURE

被引：4

作者：

DREXLER, H ^{[1
]}

TRUOG, AG ^{[1
]}

JUST, H ^{[1
]}

ZELIS, R ^{[1
]}

机构：

[1] PENN STATE UNIV, MILTON S HERSHEY MED CTR,DIV CARDIOL, HERSHEY, PA 17033 USA

来源：

KLINISCHE WOCHENSCHRIFT | 1985年 / 63卷 / 06期

关键词：

DILTIAZEM HYDROCHLORIDE CRD-401; VENTRICULAR-FUNCTION; HEMODYNAMICS; CAPTOPRIL; EXERCISE; HYDRALAZINE; CORONARY;

D O I：

10.1007/BF01731472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The regional vascular effects (radioactive microspheres) of converting-enzyme inhibition (captopril, 1 mg/kg) and calcium-antagonism (diltiazem, 1 mg/kg) were examined in a rat model of cardiac failure due to large myocardial infarction (n = 18, infarct size 40% of the left ventricle) at rest and during submaximal treadmill exercise. Diltiazem increased renal, gastrointestinal, coronary and cutaneous blood flow at rest by 29%, 28%, 26% and 37% (P < 0.05 each) and enhanced skeletal muscle blood flow during exercise by 16% (P < 0.05). Captopril improved primarily renal and coronary blood flow at rest (by 59% and 23%, respectively, P < 0.05) and reduced vascular resistance in the gastrointestinal bed by 25% (P < 0.05) without significant effects in other circulatory beds. The regional vascular effects elicited by converting-enzyme inhibition and calcium antagonism differ considerably in this animal model of congestive heart failure and may be clinically important. The favorable regional vascular profile of diltiazem deserves further clinical investigation.

引用

页码：262 / 267

页数：6

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