QUINOLINE ESTERS AS POTENTIAL ANTIMALARIAL-DRUGS - EFFECT ON RELAPSES OF PLASMODIUM-CYNOMOLGI INFECTIONS IN MONKEYS

被引：29

作者：

PURI, SK

DUTTA, GP

机构：

[1] Division of Microbiology, Central Drug Research Institute, Lucknow

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 06期

关键词：

D O I：

10.1016/0035-9203(90)90066-N

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Two compounds of the quinoline ester series, WR 197236 (6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline) and WR 194905 (4-acetoxy-6-decyloxy-7-isopropoxy-3-methoxycarbonyl-quinoline), exhibit anti-relapse activity against sporozoite-induced Plasmodium cynomolgi B infections in rhesus monkeys. Both the compounds have been found to be curative when given intramusculary in 7 daily doses of 15 mg/kg, and no relapses were observed during the observation period of 120 d.

引用

页码：759 / 760

页数：2

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