HIGH EXPRESSION OF MANGANESE SUPEROXIDE-DISMUTASE IN 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED OVARIAN-CANCER AND INCREASED SERUM LEVELS IN THE TUMOR-BEARING RATS

被引：11

作者：

NAKATA, T

SUZUKI, K

FUJII, J

ISHIKAWA, M

TATSUMI, H

SUGIYAMA, T

NISHIDA, T

SHIMIZU, T

YAKUSHIJI, M

TANIGUCHI, N

机构：

[1] OSAKA UNIV,SCH MED,DEPT BIOCHEM,SUITA,OSAKA 565,JAPAN

[2] SAPPORO MED COLL,DEPT ANAT,SAPPORO,HOKKAIDO 060,JAPAN

[3] KURUME UNIV,SCH MED,DEPT OBSTET GYNECOL,KURUME,FUKUOKA 830,JAPAN

[4] ASAHIKAWA MED COLL,DEPT OBSTET & GYNECOL,ASAHIKAWA 078,JAPAN

来源：

CARCINOGENESIS | 1992年 / 13卷 / 10期

关键词：

D O I：

10.1093/carcin/13.10.1941

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Manganese superoxide dismutase (Mn-SOD) is strongly expressed in human ovarian cancer, and the serum level of the enzyme is a useful marker for the diagnosis and monitoring of human ovarian cancer. In the present study we found that Mn-SOD was highly expressed in primary and transplanted ovarian cancers in rats induced by 7,12-dimethylbenz[a]anthracene (DMBA), as judged by enzyme-linked immunosorbent assay as well as by Northern blot analysis. The serum levels of Mn-SOD in the tumor-bearing rats were also higher than those in control rats. The antibody strongly reacted with rat ovarian carcinoma tissues. These data suggest that DMBA-induced ovarian cancer in rats is a good experimental model for human ovarian cancer, and that Mn-SOD is also a good marker for disease in the animal model.

引用

页码：1941 / 1943

页数：3

共 20 条

[1]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[2] MANGANESE SUPEROXIDE-DISMUTASE - NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF A CDNA-ENCODING A NEW HUMAN TRANSCRIPT [J].