PHENOTYPIC AND FUNCTIONAL CONSEQUENCES OF HERPESVIRUS SAIMIRI INFECTION OF HUMAN CD8+ CYTOTOXIC T-LYMPHOCYTES

被引：31

作者：

BEREND, KR

JUNG, JU

BOYLE, TJ

DIMAIO, JM

MUNGAL, SA

DESROSIERS, RC

LYERLY, HK

机构：

[1] DUKE UNIV,MED CTR,DEPT SURG,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710

[3] HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,SOUTHBOROUGH,MA 01772

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 10期

关键词：

D O I：

10.1128/JVI.67.10.6317-6321.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

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页码：6317 / 6321

页数：5

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