PAX GENES - WHATS NEW IN DEVELOPMENTAL BIOLOGY AND CANCER

被引：52

作者：

STUART, ET

GRUSS, P

机构：

[1] Department of Molecular Cell Biology, Max Planck Inst. Biophysical Chem., D-37077 Göttingen, Am Fassberg

来源：

HUMAN MOLECULAR GENETICS | 1995年 / 4卷

关键词：

D O I：

10.1093/hmg/4.suppl_1.1717

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PAX genes encode nuclear transcription factors which are rapidly becoming regarded as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine Pax genes underlie three natural mouse alleles and two corresponding human syndromes. Murine Pax genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers. The diversity in effects of PAX genes reflects that of their structure. All encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain-the paired type-homeobox.

引用

页码：1717 / 1720

页数：4

共 52 条

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