NEW ANTITUMORAL CYCLOPEPTIDES

被引：2

作者：

BERNARDI, E

FAUCHERE, JL

ATASSI, G

VIALLEFONT, P

LAZARO, R

机构：

[1] UNIV MONTPELLIER 2,CNRS,URA 468,F-34095 MONTPELLIER 5,FRANCE

[2] INST RECH SERVIER,F-92150 SURESNES,FRANCE

来源：

AMINO ACIDS | 1994年 / 6卷 / 03期

关键词：

AMINO ACIDS; PEPTIDES; CYCLOPEPTIDES; CHLAMYDOCIN; HC TOXIN; ALKYLATING AGENT; ANTITUMORAL AGENT;

D O I：

10.1007/BF00813752

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chlamydocin is a powerful in vitro antitumoral agent, quickly inactivated in vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on an epsilon-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One analog was found to be potent at inhibiting L1210 cell proliferation and had a higher therapeutic index than the reference compound bis-beta-chloroethylnitrosourea on the in vivo P388-induced leukemia model.

引用

页码：315 / 318

页数：4

共 5 条

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[3]

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[4]

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GRIEDER, A ;

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EXPERIENTIA, 1985, 41 (03) :348-350

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