HORMONAL-REGULATION OF SERUM LIPOPROTEIN(A) LEVELS - CONTRASTING EFFECTS OF GROWTH-HORMONE AND INSULIN-LIKE GROWTH-FACTOR-I

被引：56

作者：

OLIVECRONA, H

JOHANSSON, AG

LINDH, E

LJUNGHALL, S

BERGLUND, L

ANGELIN, B

机构：

[1] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT MED,S-14186 HUDDINGE,SWEDEN

[2] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT SURG,METAB UNIT,S-14186 HUDDINGE,SWEDEN

[3] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT CLIN CHEM,S-14186 HUDDINGE,SWEDEN

[4] HUDDINGE UNIV HOSP,KAROLINSKA INST,CTR NUTR & TOXICOL,MOLEC NUTR UNIT,S-14186 HUDDINGE,SWEDEN

[5] UNIV UPPSALA HOSP,DEPT INTERNAL MED,S-75185 UPPSALA,SWEDEN

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 1995年 / 15卷 / 07期

关键词：

GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR-I; LIPOPROTEIN;

D O I：

10.1161/01.ATV.15.7.847

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In response to treatment with growth hormone, serum levels of lipoprotein(a) increase, while those of LDL cholesterol decrease. To establish if increased levels of insulinlike growth factor-I may be of importance for these changes, we analyzed serum lipoprotein concentrations in 11 male patients with idiopathic osteoporosis who were treated with growth hormone (2 IU . m(-2) . d(-1)) or insulin-like growth factor-I (80 mu g kg(-1) . d(-1)) in a randomized, double-blind, crossover study. LDL cholesterol was reduced by 0.7 mmol/L (P<.01) during growth hormone treatment but was not affected when the same patients received insulin-like growth factor-I. In contrast, mean lipoprotein(a) levels increased from 519 to 571 mg/L (P<.03) in response to growth hormone but were reduced from 538 to 478 mg/L (P<.04) during treatment with insulin-like growth factor-I. These results indicate that growth hormone exerts its effects on lipoprotein metabolism independent of insulin-like growth factor-I. Furthermore, the results suggest that treatment with insulin-like growth factor-I may reduce lipoprotein(a) levels.

引用

页码：847 / 849

页数：3

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