EFFECT OF MULTIPLE ADMINISTRATION OF ORPHENADRINE OR MONO-N-DESMETHYLORPHENADRINE ON CYTOCHROME-P-450 CATALYZED-REACTIONS IN THE RAT

被引：4

作者：

BAST, A

SAVENIJECHAPEL, EM

VANKEMENADE, FAA

SCHEEFHALS, LWC

NOORDHOEK, J

机构：

来源：

ARCHIVES OF TOXICOLOGY | 1983年 / 54卷 / 02期

关键词：

D O I：

10.1007/BF01261381

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

引用

页码：131 / 137

页数：7

共 21 条

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[2] SPECTRAL INTERACTION OF ORPHENADRINE AND ITS METABOLITES WITH OXIDIZED AND REDUCED HEPATIC-MICROSOMAL CYTOCHROME-P-450 IN THE RAT [J].

BAST, A ;

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[3] EVALUATION AND COMPARISON OF COLORIMETRIC, RADIOMETRIC AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAYS FOR AMINOPYRINE-N-DEMETHYLATION BY RAT-LIVER MICROSOMES [J].

BAST, A ;

NOORDHOEK, J .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1981, 33 (01) :14-18

[4] CALCULATION OF COMPETITIVE-INHIBITION OF SUBSTRATE BINDING TO CYTOCHROME-P-450 ILLUSTRATED BY THE INTERACTION OF D,L-PROPRANOLOL WITH D,L-HEXOBARBITAL [J].

BAST, A ;

NOORDHOEK, J .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (05) :747-751

[5] PRODUCT INHIBITION DURING THE HEPATIC-MICROSOMAL N-DEMETHYLATION OF AMINOPYRINE IN THE RAT [J].

BAST, A ;

NOORDHOEK, J .

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[6]

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[7]

Estabrook RW., 1972, METHODS PHARM, Vvol 2, P303

[8] INHIBITION OF MIXED-FUNCTION OXIDATIONS BY SUBSTRATES FORMING REDUCED CYTOCHROME-P-450 METABOLIC-INTERMEDIATE COMPLEXES [J].

FRANKLIN, MR .

PHARMACOLOGY & THERAPEUTICS PART A-CHEMOTHERAPY TOXICOLOGY AND METABOLIC INHIBITORS, 1977, 2 (01) :227-245

[9]

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[10]

GIBALDI M, 1975, PHARMACOKINETICS

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